Apraclonidine—An eye opener

Pharmacological testing with apraclonidine eye drops induces a typical reversal of anisocoria in patients Horner’s syndrome. Moreover, was observed to have an elevating effect on the upper eyelid syndrome as well healthy subjects, which is thought be mediated by alpha-1 adrenergic receptors present Muller’s muscle. We aim quantitatively investigate position compared physiological based infrared video recordings from pupillometry. included 36 for analysis who underwent binocular pupillometry before and after 1% evaluation anisocoria. Vertical measurements were taken videos averaged multiple cycles. Receiver operating characteristic curves calculated determine optimal cutoff value change aperture pre- post-apraclonidine. A decrease inter-eye difference >0.42 mm discriminative sensitivity 80% specificity 75%. Our data confirm eyelid- test, more pronounced eyes sympathetic denervation deficit. Measuring may improve diagnostic accuracy